GLP-1 Receptor Agonists
Glucagon-like peptide-1 (GLP-1) receptor agonists represent a revolutionary class of medications primarily used for the treatment of type 2 diabetes and, more recently, for weight management. BiochemAPI specializes in the synthesis and supply of high-quality GLP-1 receptor agonist raw materials, including Semaglutide, Tirzepatide, and Retatrutide, for pharmaceutical research, development, and production.
Our cutting-edge manufacturing processes and rigorous quality control ensure that all our GLP-1 materials meet the highest standards of purity and consistency, making them suitable for both research applications and pharmaceutical manufacturing.
Semaglutide
Structure & Properties
Chemical Name: C187H291N45O59
Molecular Formula: C187H291N45O59
Molecular Weight: 4113.58 g/mol
CAS Number: 910463-68-2
Purity: ≥99%
Description
Semaglutide is a GLP-1 receptor agonist with 94% sequence homology to native human GLP-1. It features a C18 fatty diacid side chain attached to lysine at position 26 via a spacer, giving it enhanced albumin binding and a significantly extended half-life compared to native GLP-1. This structural modification results in a once-weekly dosing regimen, improving patient compliance.
BiochemAPI produces high-purity Semaglutide raw materials using advanced solid-phase peptide synthesis techniques followed by precise chemical modifications. Our Semaglutide meets stringent quality standards and is suitable for pharmaceutical applications.
Applications
- Treatment of type 2 diabetes (T2D)
- Weight management for obesity
- Cardiovascular risk reduction in adults with T2D
- Research into potential applications for NASH and other metabolic disorders
Tirzepatide
Structure & Properties
Chemical Name: 39-L-Lysine-C2′-L-threonine-C24-N6.N6.N6-tris[2-(2-{2-[2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl], 15-L-glutamic acid, 20-L-serine-glucitol, glucagon-like insulinotropic peptide [1-39]-peptidyl-L-2-aminobutanoyl-2-[2-(2-aminoethoxy)ethoxy]acetic acid
Molecular Formula: C225H348N48O68
Molecular Weight: 4813.5 g/mol
CAS Number: 2023788-19-2
Purity: ≥99%
Description
Tirzepatide is a novel dual GIP and GLP-1 receptor agonist (also known as a "twincretin"). It is a 39-amino acid synthetic linear peptide that binds to both the GLP-1 receptor and the glucose-dependent insulinotropic polypeptide (GIP) receptor. The molecule features a C20 fatty diacid moiety that enables strong albumin binding, extending its half-life to approximately 5 days.
BiochemAPI synthesizes Tirzepatide using a combination of solid-phase peptide synthesis and solution-phase chemistry to achieve the complex structural features required for its dual receptor activity. Our Tirzepatide is produced under stringent quality control conditions to ensure consistent high purity.
Applications
- Treatment of type 2 diabetes (T2D)
- Weight management for obesity with enhanced efficacy compared to GLP-1 receptor agonists alone
- Research into cardiovascular outcomes
- Investigation into potential benefits for NASH and other metabolic conditions
Retatrutide
Structure & Properties
Chemical Name: Tri-agonist peptide targeting GLP-1, glucagon, and GIP receptors
Molecular Weight: ~4950 g/mol
Purity: ≥99%
Description
Retatrutide is an innovative tri-agonist peptide that simultaneously activates three receptors: GLP-1, glucagon, and glucose-dependent insulinotropic polypeptide (GIP). This triple action represents the next generation of incretin-based therapies. The peptide features structural modifications that allow balanced activation of all three receptors while maintaining a favorable pharmacokinetic profile with weekly dosing potential.
BiochemAPI has developed specialized synthesis protocols for producing high-purity Retatrutide, addressing the unique challenges of creating a peptide with balanced tri-receptor activity. Our manufacturing process ensures consistent quality and structural integrity of this complex molecule.
Applications
- Treatment of obesity with potentially superior weight loss outcomes compared to dual- or mono-agonists
- Management of type 2 diabetes
- Research into metabolic syndrome and related conditions
- Investigation of effects on liver fat reduction and NASH
Custom GLP-1 Synthesis
In addition to our catalog of GLP-1 receptor agonists, BiochemAPI offers custom synthesis services for novel GLP-1 analogs, fragments, and derivatives. Our team of experienced peptide chemists can synthesize custom-designed GLP-1-related compounds according to your specifications, with options for various modifications including:
- Novel amino acid substitutions
- Custom fatty acid attachments
- Alternative linker chemistries
- Fluorescent or biotin labeling
- Truncated or extended sequences
- Cyclization and other conformational constraints
Our custom synthesis services are backed by comprehensive analytical characterization, including mass spectrometry, HPLC purity analysis, and amino acid analysis. We can scale from milligram quantities for initial research to gram-scale production for preclinical and early clinical studies.